منابع مشابه
Beyond Missing Heritability: Prediction of Complex Traits
Despite rapid advances in genomic technology, our ability to account for phenotypic variation using genetic information remains limited for many traits. This has unfortunately resulted in limited application of genetic data towards preventive and personalized medicine, one of the primary impetuses of genome-wide association studies. Recently, a large proportion of the "missing heritability" for...
متن کاملBeyond Heritability: Twin Studies in Behavioral Research.
The heritability of human behavioral traits is now well established, due in large measure to classical twin studies. We see little need for further studies of the heritability of individual traits in behavioral science, but the twin study is far from having outlived its usefulness. The existence of pervasive familial influences on behavior means that selection bias is always a concern in any st...
متن کاملChildhood and adolescent anxiety and depression: beyond heritability.
OBJECTIVE To review the methodology of behavior genetics studies addressing research questions that go beyond simple heritability estimation and illustrate these using representative research on childhood and adolescent anxiety and depression. METHOD The classic twin design and its extensions may be used to examine age and gender differences in the genetic determinants of complex traits and d...
متن کاملInheritance Beyond Plain Heritability: Variance-Controlling Genes in Arabidopsis thaliana
The phenotypic effect of a gene is normally described by the mean-difference between alternative genotypes. A gene may, however, also influence the phenotype by causing a difference in variance between genotypes. Here, we reanalyze a publicly available Arabidopsis thaliana dataset [1] and show that genetic variance heterogeneity appears to be as common as normal additive effects on a genomewide...
متن کاملHeritability
What in your view is the distinguishing feature of developmental biology with respect to other natural sciences? It is the source of causality, the genome. Developmental biology differs from other sciences, physics, for example, most profoundly because of the organizing role of the primary informational content of the genome. The genomes of animals are the unique products of a billion years of ...
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ژورنال
عنوان ژورنال: Current Directions in Psychological Science
سال: 2009
ISSN: 0963-7214,1467-8721
DOI: 10.1111/j.1467-8721.2009.01639.x